diff --git a/esphome/components/hmac_md5/hmac_md5.cpp b/esphome/components/hmac_md5/hmac_md5.cpp
index 90bf91882f..d766a55fab 100644
--- a/esphome/components/hmac_md5/hmac_md5.cpp
+++ b/esphome/components/hmac_md5/hmac_md5.cpp
@@ -1,6 +1,7 @@
 #include <cstdio>
 #include <cstring>
 #include "hmac_md5.h"
+#ifdef USE_MD5
 #include "esphome/core/helpers.h"
 
 namespace esphome {
@@ -54,3 +55,4 @@ bool HmacMD5::equals_hex(const char *expected) { return this->ohash_.equals_hex(
 
 }  // namespace hmac_md5
 }  // namespace esphome
+#endif
diff --git a/esphome/components/hmac_md5/hmac_md5.h b/esphome/components/hmac_md5/hmac_md5.h
index 81597c1acc..b83b9d5421 100644
--- a/esphome/components/hmac_md5/hmac_md5.h
+++ b/esphome/components/hmac_md5/hmac_md5.h
@@ -1,8 +1,8 @@
 #pragma once
 
 #include "esphome/core/defines.h"
+#ifdef USE_MD5
 #include "esphome/components/md5/md5.h"
-#ifndef USE_ZEPHYR
 #include <string>
 
 namespace esphome {
diff --git a/esphome/components/md5/__init__.py b/esphome/components/md5/__init__.py
index f70ffa9520..1af9ee0b29 100644
--- a/esphome/components/md5/__init__.py
+++ b/esphome/components/md5/__init__.py
@@ -1 +1,7 @@
+import esphome.codegen as cg
+
 CODEOWNERS = ["@esphome/core"]
+
+
+async def to_code(config):
+    cg.add_define("USE_MD5")
diff --git a/esphome/components/md5/md5.cpp b/esphome/components/md5/md5.cpp
index 620b6749f3..31f52634be 100644
--- a/esphome/components/md5/md5.cpp
+++ b/esphome/components/md5/md5.cpp
@@ -1,6 +1,7 @@
 #include <cstdio>
 #include <cstring>
 #include "md5.h"
+#ifdef USE_MD5
 #include "esphome/core/helpers.h"
 
 namespace esphome {
@@ -65,3 +66,4 @@ bool MD5Digest::equals_hex(const char *expected) {
 
 }  // namespace md5
 }  // namespace esphome
+#endif
diff --git a/esphome/components/md5/md5.h b/esphome/components/md5/md5.h
index c0aae62aca..cb6accf46f 100644
--- a/esphome/components/md5/md5.h
+++ b/esphome/components/md5/md5.h
@@ -1,6 +1,7 @@
 #pragma once
 
 #include "esphome/core/defines.h"
+#ifdef USE_MD5
 
 #ifdef USE_ESP_IDF
 #include "esp_rom_md5.h"
@@ -27,8 +28,6 @@
 #define MD5_CTX_TYPE LT_MD5_CTX_T
 #endif
 
-#ifndef USE_ZEPHYR
-
 namespace esphome {
 namespace md5 {
 
diff --git a/esphome/core/defines.h b/esphome/core/defines.h
index f2d4e0d7f5..277e1ffc39 100644
--- a/esphome/core/defines.h
+++ b/esphome/core/defines.h
@@ -45,6 +45,7 @@
 #define USE_LVGL_KEY_LISTENER
 #define USE_LVGL_TOUCHSCREEN
 #define USE_LVGL_ROTARY_ENCODER
+#define USE_MD5
 #define USE_MDNS
 #define USE_MEDIA_PLAYER
 #define USE_NEXTION_TFT_UPLOAD