diff --git a/esphome/components/ota/__init__.py b/esphome/components/ota/__init__.py
index 9da676f6e3..995f31256c 100644
--- a/esphome/components/ota/__init__.py
+++ b/esphome/components/ota/__init__.py
@@ -15,6 +15,7 @@ from esphome.const import (
     CONF_VERSION,
 )
 from esphome.core import CORE, coroutine_with_priority
+import esphome.final_validate as fv
 
 CODEOWNERS = ["@esphome/core"]
 
@@ -114,6 +115,20 @@ CONFIG_SCHEMA = cv.Schema(
 ).extend(cv.COMPONENT_SCHEMA)
 
 
+def _validate_mcumgr(config):
+    if CORE.using_zephyr:
+        fconf = fv.full_config.get()
+        try:
+            bootloader = fconf.get_config_for_path(["nrf52", "bootloader"])
+            if bootloader != "mcuboot":
+                raise cv.Invalid(f"'{bootloader}' bootloader does not support OTA")
+        except KeyError:
+            pass
+
+
+FINAL_VALIDATE_SCHEMA = _validate_mcumgr
+
+
 @coroutine_with_priority(50.0)
 async def to_code(config):
     CORE.data[CONF_OTA] = {}