diff --git a/esphome/components/htu21d/htu21d.cpp b/esphome/components/htu21d/htu21d.cpp
index a7aae16f17..c5d91d3dd0 100644
--- a/esphome/components/htu21d/htu21d.cpp
+++ b/esphome/components/htu21d/htu21d.cpp
@@ -9,8 +9,8 @@ static const char *const TAG = "htu21d";
 
 static const uint8_t HTU21D_ADDRESS = 0x40;
 static const uint8_t HTU21D_REGISTER_RESET = 0xFE;
-static const uint8_t HTU21D_REGISTER_TEMPERATURE = 0xE3;
-static const uint8_t HTU21D_REGISTER_HUMIDITY = 0xE5;
+static const uint8_t HTU21D_REGISTER_TEMPERATURE = 0xF3;
+static const uint8_t HTU21D_REGISTER_HUMIDITY = 0xF5;
 static const uint8_t HTU21D_WRITERHT_REG_CMD = 0xE6; /**< Write RH/T User Register 1 */
 static const uint8_t HTU21D_REGISTER_STATUS = 0xE7;
 static const uint8_t HTU21D_WRITEHEATER_REG_CMD = 0x51; /**< Write Heater Control Register */