diff --git a/esphome/components/usb_uart/usb_uart.cpp b/esphome/components/usb_uart/usb_uart.cpp
index 86a47e6f56..60c4720e96 100644
--- a/esphome/components/usb_uart/usb_uart.cpp
+++ b/esphome/components/usb_uart/usb_uart.cpp
@@ -330,7 +330,7 @@ void USBUartTypeCdcAcm::on_connected() {
     channel->cdc_dev_ = cdc_devs[i++];
     fix_mps(channel->cdc_dev_.in_ep);
     fix_mps(channel->cdc_dev_.out_ep);
-    channel->initialised_ = true;
+    channel->initialised_.store(true);
     auto err =
         usb_host_interface_claim(this->handle_, this->device_handle_, channel->cdc_dev_.bulk_interface_number, 0);
     if (err != ESP_OK) {