diff --git a/script/analyze_component_buses.py b/script/analyze_component_buses.py
index 3153a5b1dd..2818cc41b1 100644
--- a/script/analyze_component_buses.py
+++ b/script/analyze_component_buses.py
@@ -50,6 +50,18 @@ VALID_BUS_CONFIGS = {
     "uart_9600_even",
 }
 
+# Bus types that support component grouping
+# I2C and SPI are shared buses with addressing/CS pins
+# BLE sensors scan independently and don't conflict
+# UART is point-to-point and components would conflict on the same bus
+GROUPABLE_BUS_TYPES = {
+    "ble",
+    "i2c",
+    "i2c_low_freq",
+    "qspi",
+    "spi",
+}
+
 
 def uses_local_file_references(component_dir: Path) -> bool:
     """Check if a component uses local file references via $component_dir.
@@ -182,18 +194,26 @@ def create_grouping_signature(
     """Create a signature string for grouping components.
 
     Components with the same signature can be grouped together for testing.
+    Only includes groupable bus types (I2C, SPI, BLE) - excludes point-to-point
+    protocols like UART that can't be shared.
 
     Args:
         platform_buses: Mapping of platform to list of buses
         platform: The specific platform to create signature for
 
     Returns:
-        Signature string (e.g., "i2c+uart_19200" or "spi")
+        Signature string (e.g., "i2c" or "spi") or empty if no groupable buses
     """
     buses = platform_buses.get(platform, [])
     if not buses:
         return ""
-    return "+".join(sorted(buses))
+
+    # Only include groupable bus types in signature
+    groupable_buses = [b for b in buses if b in GROUPABLE_BUS_TYPES]
+    if not groupable_buses:
+        return ""
+
+    return "+".join(sorted(groupable_buses))
 
 
 def group_components_by_signature(
diff --git a/script/test_build_components.py b/script/test_build_components.py
index 959f1e3ac3..098af6906c 100755
--- a/script/test_build_components.py
+++ b/script/test_build_components.py
@@ -332,10 +332,13 @@ def run_grouped_component_tests(
             if platform_filter and not platform.startswith(platform_filter):
                 continue
 
-            # Only group if component has common bus configs
+            # Only group if component has groupable bus configs
             if buses:
                 signature = create_grouping_signature({platform: buses}, platform)
-                grouped_components[(platform, signature)].append(component)
+                # Only add to grouped_components if signature is non-empty
+                # (empty means only non-groupable buses like UART)
+                if signature:
+                    grouped_components[(platform, signature)].append(component)
 
     # Print detailed grouping plan
     print("\nGrouping Plan:")