diff --git a/esphome/components/sensirion_common/i2c_sensirion.cpp b/esphome/components/sensirion_common/i2c_sensirion.cpp
index 9eac6b4525..e39a3ce0a0 100644
--- a/esphome/components/sensirion_common/i2c_sensirion.cpp
+++ b/esphome/components/sensirion_common/i2c_sensirion.cpp
@@ -57,24 +57,14 @@ bool SensirionI2CDevice::write_command_(uint16_t command, CommandLen command_len
     temp[raw_idx++] = command & 0xFF;
   } else {
     // command is 2 bytes
-#if __BYTE_ORDER__ == __ORDER_LITTLE_ENDIAN__
     temp[raw_idx++] = command >> 8;
     temp[raw_idx++] = command & 0xFF;
-#else
-    temp[raw_idx++] = command & 0xFF;
-    temp[raw_idx++] = command >> 8;
-#endif
   }
   // add parameters followed by crc
   // skipped if len == 0
   for (size_t i = 0; i < data_len; i++) {
-#if __BYTE_ORDER__ == __ORDER_LITTLE_ENDIAN__
     temp[raw_idx++] = data[i] >> 8;
     temp[raw_idx++] = data[i] & 0xFF;
-#else
-    temp[raw_idx++] = data[i] & 0xFF;
-    temp[raw_idx++] = data[i] >> 8;
-#endif
     // Use MSB first since Sensirion devices use CRC-8 with MSB first
     uint8_t crc = crc8(&temp[raw_idx - 2], 2, 0xFF, CRC_POLYNOMIAL, true);
     temp[raw_idx++] = crc;